The size of the particles is called particle size. The particle size of the API is closely related to the homogeneity of the preparation process in terms of mixing, the accuracy of dosage, and compressibility, and it has an impact on the solubility, duration of action, site of action, stability, and safety of the drug formulation. And the particle size control of drugs has an important influence on drug effectiveness, strength, and security. Therefore, particle size is an essential object of study in preformulation studies for innovative medicines. Preformulation research is a vital link in drug development, directly affecting the subsequent development process and final application of drugs

The vaccine is a generic term for various biological products containing antigenic substances that induce specific active immunity in humans. In preclinical studies of vaccine, it is crucial to examine the safety of vaccines by performing preclinical safety evaluations with relevant animals. Drug safety evaluation in preclinical studies of new medicines refers to the use of greater than clinical doses or more prolonged than clinical dosing times to administer drugs to animals to discover and evaluate the potential toxic effects on the animal organism, the manifestations of toxicity, and the reversibility of target organ damage. This study helps to find toxic doses,detect harmful effects, det

Toxicokinetics is an essential element of preclinical studies of drugs. As an interdisciplinary discipline between pharmacokinetics and toxicology, toxicokinetics is a bridge and tool for advancing preclinical studies to clinical studies. The primary goal of toxicokinetic studies is to demonstrate the systematic exposure levels of new drugs in test animals during safety evaluation and their correlation with the administered dose and the course over time. Their studies generally include single-dose studies in toxicity studies, multiple-dose studies, tissue distribution studies, genotoxicity studies, carcinogenicity tests, reproductive toxicity studies, and toxicokinetic studies for specific d

According to the drug development process, new drug development can be divided into preclinical and clinical studies. The former is the sum of all the research work done on a drug before it enters clinical trials, and the latter is the research work done on a drug in clinical trials. From the discovery of a drug's effectiveness in animals to its testing in human clinical trials, researchers do a great deal of work to ensure that the potential for a cure to be effective is maximized while minimizing the potential for harm. Medicilon is a preclinical research outsourcing (CRO) company that can provide customized preclinical trial service solutions to clients with years of experience in R&D

The first challenge in drug development is preclinical research of new drugs, which refers to chemical synthesis or natural product purification studies, drug analysis studies, pharmacodynamics, pharmacokinetics, toxicology, and pharmacology studies performed before a drug enters clinical studies. Preclinical studies of new medicines escort the development of innovative drugs. To New drug registration, it's vital to conduct preclinical research, including studies on the synthesis process, extraction method, physicochemical properties and purity, dosage form selection, prescription screening, preparation process, testing method, quality standard, stability, pharmacology, toxicology, animal ph

The purpose of drug development is to find new safe, effective drugs of high quality and stability to cure diseases and save lives. Developing a new drug is a very complex process, but it can be divided into preclinical research and clinical studies of a new drug.  Preclinical research is the first challenge in drug development, and preclinical toxicity studies of new medicines are an essential part of the journey from the laboratory to the clinic. Since many studies closely related to the safety of subjects, such as drug distribution, reproductive toxicity, and carcinogenicity studies, cannot be performed on issues in clinical trials, animal experiments have an irreplaceable role.  However,

In drug development, Radioisotope labeling has become a powerful tool. It provides a means to track the fate of drugs in the body and helps researchers to better understand the metabolic processes and potential toxicity of new compounds. So, scientists can design more effective and safer drugs, reducing the risk of adverse effects and increasing the likelihood of success in clinical trials. Isotopes are atoms of the same chemical element with different masses due to the presence of different neutron numbers in the nucleus, and there are light and heavy isotopes; based on physical properties, isotopes can also be classified into two forms: radioactive and stable. Radioisotope labeling technol

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The Ad Incentive Program will pay streamers a guaranteed minimum amount of ad revenue per month Twitch is implementing a new initiative that could alleviate one of the biggest stressors of content creation: unreliable income. The Ad Incentive Program, or AIP, is a new program that will pay select streamers a guaranteed monthly minimum amount of ad revenue. Qualified affiliate or partner streamers will receive a notification from Twitch offering them different payouts based on the amount of ads run per hour and total hours streamed. In the example Twitch provided, if a creator streamed for at least 40 hours that month, they could receive $100 for running two minutes of ads per hour, $300 fo

After thoroughly indulging this past holiday season, I find myself already day dreaming about the goodies to come next year!My partner's mum always makes the most delicious food, especially for the holidays. Over the past couple of years, I have had the honour of rolling up my sleeves and helping her out in the kitchen. It's been great learning new recipes and sharing one or two of my own with her.She makes and bakes her heart out including some amazing shortbread cookies (simple yet delicious), pan forte, many different types of cakes, slices, and these amazing cookies that are a combination of a fancy gingerbread like dough that also have jam thumbprints in them and even have dark chocolat

SHODASI : SECRETS OF THE RAMAYANA ENGLISH   HINDI AND TELUGU ORIGINAL AUTHOR : SESHENDRA SHARMA Seshendra : Visionary Poet of the Millennium http://seshendrasharma.weebly.com www.seshen.tributes.in  REVIEWS : www.facebook.com/shodasi / Books : https://kinige.com/author/Gunturu+Seshendra+Sharma       Ramayana, a replica of Vedas S. VARADARAJAN There are several versions of the Sri Ramayana, one of the two greatest epics. Following Sri Valmiki Ramayana several editions have been published in various languages, besides scores of commentaries written across centuries. Late. Gunturu Seshendra Sharma, scholar poet of 20th Century unearthed secrets of the Ramayana through his popular Telugu book “S